| ncRNA name | hsa-let-7b |
| ncRNA Category | miRNA |
| Disease name | age-related cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | anterior lens capsule; human lens epithelial cell line SRA01/04 |
| Methods | qRT-PCR, flow cytometry, Western blot, luciferase reporter assay |
| Expression pattern | up-regulated |
| Functional description | We showed that leucine-rich repeat containing G protein-coupled receptor 4 (Lgr4) was a direct target of let-7b, and let-7b modulated lens epithelial cell apoptosis by directly targeting Lgr4. |
| PubMed ID | 27179410 |
| Year | 2016 |
| Title | MicroRNA let-7b induces lens epithelial cell apoptosis by targeting leucine-rich repeat containing G protein-coupled receptor 4 (Lgr4) in age-related cataract. |
| Drug-related ncRNA | NO |
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